| Name | PlyV12 |
| Recommended Name ? | N-acetylmuramoyl-L-alanine amidase |
| Systematic Name ? | peptidoglycan amidohydrolase |
| Alternative Name ? | endolysin PlyV12
acetylmuramoyl-alanine amidase acetylmuramyl-alanine amidase acetylmuramyl-L-alanine amidase N-acetylmuramic acid L-alanine amidase N-acetylmuramyl-L-alanine amidase N-acetylmuramylalanine amidase N-acylmuramyl-L-alanine amidase peptidoglycan amidohydrolase |
| Uniprot ID | Q6E4B1 |
| General Mode of Action | Enzymatic cleavage of peptidoglycan which results in a rapid lysis of the bacterial cell. |
| phiBIOTICS Family ? | NAM amidase |
| Reaction ? | 1. Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides (R04112) EC: 3.5.1.28 Corresponding Pfam domain: Amidase_5 Evidence: predicted (PubMed: 15231813) |
| Source Organism ? | Enterococcus sp. phage 1 |
| Target Organism ? | Enterococcus faecalis Enterococcus faecium Streptococcus pyogenes Streptococcus agalactiae |
| Note on Target | S. pyogenes is also known as Group A Streptococcus.S. agalactiae is also known as Group B Streptococcus.PlyV12 also target Group C, E and G streptococci. |
| Disease ? | Bacteremia (Enterococcus faecium; faecalis) Infective endocarditis (Enterococcus faecium; faecalis) Neonatal sepsis (Group B Streptococcus) Nosocomial infections (Enterococcus faecium; faecalis) Postpartum infections (Group B Streptococcus) Urinary track infections, Females (Enterococcus faecium; faecalis) Urinary track infections, Males (Enterococcus faecium; faecalis) Wound infections (Enterococcus faecium; faecalis) |
| State ? | Tested |
| Reference ? | 15231813 |