| Name | LysH5 |
| Recommended Name ? | lysH5 |
| Systematic Name ? | peptidoglycan amidohydrolase |
| Alternative Name ? | endolysin LysH5
acetylmuramoyl-alanine amidase acetylmuramyl-alanine amidase acetylmuramyl-L-alanine amidase N-acetylmuramic acid L-alanine amidase N-acetylmuramyl-L-alanine amidase N-acetylmuramylalanine amidase N-acylmuramyl-L-alanine amidase peptidoglycan amidohydrolase |
| Uniprot ID | B8QIR1 |
| General Mode of Action | Enzymatic cleavage of peptidoglycan which results in a rapid lysis of the bacterial cell. |
| phiBIOTICS Family ? | NAM amidase |
| Reaction ? | 1. Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides EC: 3.5.1.28 Corresponding Pfam domain: Amidase_2 Evidence: predicted (PubMed: 18809219) 2. Catalysis of the hydrolysis of the bonds in cell wall peptidoglycans (amidohydrolase/peptidase activity) EC: n/a Corresponding Pfam domain: CHAP Evidence: predicted (PubMed: 18809219) |
| Source Organism ? | Staphylococcus phage phiH5 |
| Target Organism ? | Staphylococcus aureus Staphylococcus epidermidis |
| Note on Target | LysH5 target both human and bovine Staphylococcus aureus. |
| Disease ? | Infective endocarditis (Staphylococcus epidermidis) Infective endocarditis (Staphylococcus aureus) Nosocomial infections (Staphylococcus aureus) Osteomyelitis (Staphylococcus aureus) Pneumonia (Staphylococcus aureus) |
| State ? | Tested |
| Reference ? | 18809219 |