| Name | ZooA |
| Recommended Name ? | zoocin A endopeptidase |
| Alternative Name ? | bacteriocin ZooA
metalloendoprotease metalloendoproteinase |
| Uniprot ID | O54308 |
| General Mode of Action | Enzymatic cleavage of peptidoglycan which results in a rapid lysis of the bacterial cell. |
| phiBIOTICS Family ? | Metallopeptidase |
| Reaction ? | 1. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions EC: 3.4.24.- Corresponding Pfam domain: Peptidase_M23 Evidence: experimental (PubMed: 8953725) |
| Source Organism ? | Streptococcus equi subsp. zooepidemicus |
| Target Organism ? | Streptococcus pyogenes Streptococcus equi Streptococcus mutans |
| Disease ? | Acute glomerulonephritis (Group A Streptococcus) Acute rheumatic fever (Group A Streptococcus) Dental infections (Streptococcus mutans) Impetigo (Group A Streptococcus) Infective endocarditis (Group A Streptococcus) Pharyngitis (Group A Streptococcus) Rheumatic heart disease (Group A Streptococcus) Scarlet fever (Group A Streptococcus) |
| State ? | Tested |
| Reference ? | 8953725 9168135 |